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Zerit Zerit (Stavudine) helps manage human immunodeficiency virus (HIV) infection.


Active ingredient:
Brand Name: Zerit
Incorrect generic name: Stavudine
Categories: antivirals

Synonym(s): STV, d4T, Stavudin, Stavudine, Estavudina, Stavudinum, Sanilvudine, 3′-Deoxy-2′-thymidinene, 2′,3′-Didehydro-3′-deoxythimidine
It is also sold under the brand name(s): Zerit, Zerit – Cap 40mg, Zerit – Cap 30mg, Zerit – Cap 20mg, Zerit – Cap 15mg

A dideoxynucleoside analog that inhibits reverse transcriptase and has in vitro activity against HIV. [PubChem]


For the treatment of human immunovirus (HIV) infections.


Side effects include peripheral neuropathy tingling, burning, numbness, or pain in the hands or feet), fatal lactic acidosis has been reported in patients treated with stavudine (ZERIT) in combination with other antiretroviral agents, severe liver enlargement, inflammation (pain and swelling) of the liver, and liver failure.

Mechanism of action

Stavudine inhibits the activity of HIV-1 reverse transcriptase (RT) both by competing with the natural substrate dGTP and by its incorporation into viral DNA.


Stavudine is a nucleoside reverse transcriptase inhibitor (NRTI) with activity against Human Immunodeficiency Virus Type 1 (HIV-1). Stavudine is phosphorylated to active metabolites that compete for incorporation into viral DNA. They inhibit the HIV reverse transcriptase enzyme competitively and act as a chain terminator of DNA synthesis. The lack of a 3′-OH group in the incorporated nucleoside analogue prevents the formation of the 5′ to 3′ phosphodiester linkage essential for DNA chain elongation, and therefore, the viral DNA growth is terminated.


Phosphorylated intracellularly to stavudine triphosphate, the active substrate for HIV-reverse transcriptase.


Following oral administration, stavudine is rapidly absorbed (bioavailability is 68-104%).

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